SF2312 is a natural phosphonate inhibitor of enolase
网页2016年10月10日 · Natural product 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose is a reversible inhibitor of glyceraldehyde 3-phosphate dehydrogenase. Phosphopantetheinyl transferase binding and inhibition by...
Beyond ENO1, emerging roles and targeting strategies of other …
网页2023年12月19日 · Phosphonoacetohydroxamate (PhAH) and HEX are two well-studied and commercially available inhibitors. PhAH is a potent enolase inhibitor that acts as a transition-state analog. 122 PhAH is a pan-enolase inhibitor with …
SF2312 is a natural phosphonate inhibitor of Enolase
网页To develop a specific inhibitor of the glycolytic enzyme Enolase 2 for the treatment of cancers with deletion of Enolase 1, we modeled the synthetic tool compound inhibitor, Phosphonoacetohydroxamate (PhAH) into the active site of human ENO2.
Polycyclic aromatic hydrocarbon - Wikipedia
网页A polycyclic aromatic hydrocarbon (PAH) is a class of organic compounds that is composed of multiple aromatic rings. The simplest representative is naphthalene, having two aromatic rings, and the three-ring compounds anthracene and phenanthrene. PAHs are uncharged, non-polar and planar. Many are colorless.
苯丙氨酸羟化酶 - 维基百科，自由的百科全书
网页苯丙氨酸羟化酶 (英語： Phenylalanine hydroxylase，简称PheOH,或者PheH、PAH) (EC 1.14.16.1) 是一种将 苯丙氨酸 侧链上的苯环 羟基化 为 酪氨酸 的 羟化酶。 PheOH是使用 四氢生物蝶呤 (BH 4, 蝶啶 类辅因子)和亚铁离子 (Fe 2+)作为辅酶的 单加氧酶 类蛋白质三种中的一种。 在反应中，一个氧分子的两个氧原子被分别加入到BH 4 和苯丙氨酸中。 [1] PheOH催化的反应. 苯丙氨酸羟化酶是体内过量苯丙氨酸 分解代谢 的 限速 酶。 Seymour …
phah, n. meanings, etymology and more | Oxford English Dictionary
网页The only known use of the noun phah is in the late 1500s. OED's only evidence for phah is from 1593, in the writing of Gabriel Harvey, scholar and writer. phah is an imitative or expressive formation. See etymology.
PHAH Abbreviation Meaning - All Acronyms
网页Explore the primary meanings of PHAH abbreviation, including its most popular usage as Polyhalogenated Aromatic Hydrocarbons in Medical contexts. This page also provides a comprehensive look at what does PHAH stand for in other various sectors such as Biochemistry, as well as related terms and more. Share. 3.
phosphonoacetohydroxamate - Semantic Scholar
网页Structure of the bis divalent cation complex with phosphonoacetohydroxamate at the active site of enolase. Phosphonoacetohydroxamate (PhAH) is a tight-binding (Ki = 15 pM) inhibitor of enolase that is believed to mimic the aci….
Genome engineering Escherichia coli for L-DOPA …
网页2016年7月15日 · This titer is the highest achieved in metabolically engineered E. coli having PHAH activity from glucose. Genome engineering has become a powerful tool for creating useful strains in research and...
How much do PCB toxic equivalents account for PHAH toxicity …
网页Various diffuse polyhalogenated aromatic hydrocarbons (PHAHs) exert common toxicity through the aryl hydrocarbon receptor (AhR). Apex predators spatially and temporally integrate diffuse contamination and simultaneous exposure can cause additive toxicity. We investigated the extent to which PCBs, still amongst the most prevalent PHAHs ...