NKG2D-DAP10 triggers human NK cell–mediated killing via a
网页2003年5月11日 · For NKG2D-DAP10, the phosphatidylinositol 3-kinase (PI3K)-binding motif Tyr-Ile-Asn-Met (YINM) in the cytoplasmic tail of DAP10 is reminiscent of signaling modules associated with costimulation...
NKG2D-NKG2DL信号轴，肿瘤免疫治疗热门靶点 - 知乎
网页DAP10和DAP12起始不同的下游信号事件， DAP10具有一个YINM 基序，可结合PI3K的p85亚基，此外DAP10还可以与Grb2相结合，后者与Vav1紧密关联。 DAP12包含一个免疫受体酪氨酸基激活基序ITAM，此基序在NKG2D触发时被Src激酶磷酸化，这一事件允许酪氨酸激酶Syk和Zap70的结合和激活。 T细胞和幼稚NK细胞主要表达NKG2D-L亚型，因此被认为可以促进PI3K信号级联下游的细胞过程，如共刺激、细胞毒性和细胞存活。 在小鼠 …
YInMn Blue - Wikipedia
网页YInMn Blue (/jɪnmɪn/; for the chemical symbols Y for yttrium, In for indium, and Mn for manganese), also known as Oregon Blue or Mas Blue, is an inorganic blue pigment that was discovered by Mas Subramanian and his (then) graduate student, Andrew Smith, at Oregon State University in 2009. [ 1 ][ 3 ] The pigment is noteworthy for its vibrant, nea...
Signaling for Synergistic Activation of Natural Killer Cells
网页2012年12月6日 · The cytoplasmic tail of DAP10 carries a tyrosine-based signaling motif (YINM). This YINM, after phosphorylation by Src family kinases, recruits either a p85 subunit of PI3K or the small adaptor protein Grb2.
Functions of NKG2D in CD8 - Nature
网页2018年2月5日 · DAP10 uses a YINM motif to recruit PI3K and Grb2, and activate the associated pathways. Major outcomes of the signaling is enhanced TCR signaling, cytotoxicity and enhanced T-cell survival.
CD8 + T cell killing of MHC class I–deficient tumors - Nature
网页2023年8月3日 · DAP10 contains a YINM motif, which recruits the p85 adaptor of PI3K to induce the production of D-3 inositol lipids needed to recruit signaling proteins with phospholipid-binding domains to the...
NKG2D - SpringerLink
网页2016年11月28日 · Each NKG2D molecule binds to a DAP10 dimer in this fashion to form a hexameric structure capable of signal transduction. The YINM motif in the cytoplasmic region of DAP10 recruits downstream signaling molecules. DAP10 lysine 84 is also necessary for ubiquitinylation and intracellular signaling (Quatrini et al. 2015).
TREM2- and DAP12-Dependent Activation of PI3K Requires …
网页In response to ligation of TREM2, Src family kinases phosphorylate the ITAM of DAP12 and the YINM motif of DAP10, which form docking sites for the Syk and p85, with the subsequent recruitment of PLC-γ2 and Grb2.
自然杀伤NK细胞是什么-NK细胞表面标志物-赛默飞 | Thermo …
网页NK细胞属于天然淋巴细胞（ILC），天然淋巴细胞作为天然免疫系统的一部分，对于免疫监视和随后的宿主防御病毒感染和癌细胞至关重要。. 在人体中，自然杀伤（NK）细胞占循环淋巴细胞的8-20%；在实验室的近交系小鼠中，NK细胞占脾脏和骨髓淋巴细胞的2-5% [1，2 ...
KIR3DL3-HHLA2 and TMIGD2-HHLA2 pathways: The dual role
网页2023年5月1日 · SYK is recruited to phosphorylated ITAM, which causes the SLP-76 complex to be phosphorylated, while YINM couples to VAV1 and PLC-γ in the SYK-independent pathway. Downstream signals, including PLC-γ, …