They perform this function at their active site, which is like their ... and in cancer you have mutations ongoing, and you have a system of enzymes repairing DNA being able to activate them ...

Enzymes are made of proteins. They have a specifically shaped active site that recognises a certain substrate. If a random mutation happens in the coding DNA that codes for the enzyme, then the ...

which supports a mechanism in which MerB enzymes use two conserved active-site cysteines to activate the substrate. The model studies of Melnick and Parkin provide convincing evidence for the role ...

These programs were instrumental to our project because they allowed us to do 'structural studies' and whittle down which ...