Purpose: The clinical benefits, adverse effects, pharmacokinetics, and recommendations for the appropriate use of the aldosterone antagonists spironolactone and eplerenone in patients with heart ...

Aldosterone Receptor Blockers ... on survival in severely symptomatic (New York Heart Association class IV) heart failure patients taking an ACE inhibitor, loop diuretic, and digoxin.

Aldosterone is a hormone produced in the adrenal gland. This steroid molecule, derived from cholesterol, promotes retention of sodium and water and lowers the levels of potassium in the blood ...