Now, two papers highlight new ways of inhibiting androgen receptor function that could overcome such resistance problems. In the first study, published in the Proceedings of the National Academy ...

Although testosterone is also present in females and has important functions there, it is classically referred to as the ‘male hormone’: it significantly contributes to the sexual development, ...

Female androgens are derived from either the adrenal and peripheral conversion of the adrenal sex steroid precursor, dehydroepiandrosterone, or from direct ovarian production. Adrenal ...

OBJECTIVE: In women, androgens modulate the physiological function of many reproductive and sexual organs, including the ovaries, uterus, vagina, oviducts, clitoris, and mammary gland. In this ...

When such enzymes prove completely incapable of creating testosterone, the genitals appear female; when the enzymes function at a low level, ambiguous genitals form. AIS affects the section of the ...

"For decades, the goal of endocrine therapy in prostate cancer has been to achieve absolute inhibition of androgen receptor function, the protein that senses testosterone levels," said lead ...

To exert its function, testosterone binds to the so-called androgen receptor. This is then activated and triggers the production of certain proteins in the cell.