COG 133作为一种多功能的肽片段，在调节脂质代谢、抗炎、神经保护以及影响神经递质受体功能等方面展现出潜在的治疗价值。其作为nAChR拮抗剂的特性也为神经系统疾病的治疗提供了新的思路和靶点。未来，COG ...

*仅供医学专业人士阅读参考APOE4是阿尔茨海默病（AD）的最强遗传风险因素，降低AD发病年龄，促进AD的典型病理，包括β-淀粉样蛋白（Aβ）和过度磷酸化的tau蛋白（p-tau）沉积。APOE4在AD发病机制中的作用十分复杂，仍没有被完全揭示。星形 ...

"I'm using [Ozempic] off-label for a whole host of conditions — and have been for years," Dr. Caroline Messer, an ...

引言阿尔茨海默症（Alzheimer’s disease, AD）的临床前期（preclinical ...

Researchers map the unique genetic regulation of proteins in human cerebrospinal fluid, identifying potential targets for ...

Reducing microglial activity in the presence of apolipoprotein E4 (APOE4) has uncovered a mechanism associated with the deposition of misfolded amyloid and tau in a novel mouse model of Alzheimer’s ...

The link between lipid metabolism and glaucoma pathophysiology could guide future research and treatment strategies.

Patrizia Agostinis (VIB-KU Leuven) has found that melanoma cell populations protect themselves from a form of cell death called ferroptosis by secreting the lipoprotein apolipoprotein E (ApoE).

Scientists monitor mpox virus mutations and human-to-human transmission, impacting vaccination strategies in Africa.

Drs Pavan Brahmbhatt and Amit Agarwal discuss best practices for managing amyloid-related imaging abnormalities in patients ...