近日，韩国中央大学的研究团队在《自噬》（Autophagy）杂志上发表了一项重要研究成果，揭示了一种名为IU1的化合物具有潜在的抗衰老效果。这项研究不仅为理解蛋白质稳态与衰老之间的关系提供了新的见解，还可能为开发治疗年龄相关疾病的药物开辟新途径。

In 2000, it was suggested to me that “Autophagy will be the wave of the future; it will become the new apoptosis.” Few people would have agreed at the time, but this statement turned out to be ...

New research shows astrocytes can remove Alzheimer’s-related amyloid-beta via autophagy, offering a promising new direction ...

在一项新的研究中，来自英国牛津大学和新加坡南洋理工大学等研究机构的研究人员发现了一种修复受损DNA的新过程，这与因患上 结直肠癌 而接受治疗的患者特别相关。在这种过程中，细胞从细胞核中清除有害的DNA-蛋白质病变，确保其遗传物质的稳定性，促进细胞存活 ...

Aging diminishes autophagy in short-lived model organisms. This study uncouples macroautophagy and mitophagy in the aging ...

Josephine Thinwa shares her journey to becoming a physician scientist and how this led her to investigate the role of a ...

A research team has uncovered a new mechanism involving astrocytes for treating Alzheimer's disease (AD) and proposed a novel ...

An international research team led by Osaka University has identified a new mechanism crucial for the initiation of autophagy ...

近日，国家自然科学基金委公布了2024年度国家自然科学基金集中接收申请项目评审结果。哈医大肿瘤医院取得了新的突破，共获批立项28项，较去年递增40%，创历史新高。其中面上项目10项、青年科学基金18项，直接经费资助总额1027万元。

随着全球人口迅速老龄化，影响数百万老年人并严重降低其生活质量的肌肉减少症正在成为一个紧迫的公共卫生问题。现在，杜克大学-新加坡国立大学医学院的科学家们的一项新发现可能会改善这种疾病的治疗方法。 在这项发表在《Autophagy》杂志上的研究中，科学家们发现，一种叫做DEAF1 ...

Longevity-promoting regimens, including caloric restriction and inhibition of TOR with rapamycin, resveratrol or the natural polyamine spermidine, have been associated with autophagy (a ...

In mammals, autophagosome formation, a central event in autophagy, is initiated by the ULK complex comprising ULK1/2, FIP200, ATG13, and ATG101. However, the structural basis and mechanism of the ULK ...