The researchers discovered that combining venetoclax with a drug called 5-azacytidine significantly increased its effectiveness across many MM cell lines, indicating a broader potential patient ...

Two examples of these types of drugs are 5-azacytidine and 5-aza-2′-deoxycytidine (Egger et al., 2004). These medications work by acting like the nucleotide cytosine and incorporating themselves ...

A recent study evaluates the dosing, safety, and efficacy of telaglenastat and azacytidine to treat advanced myelodysplastic syndromes (MDS), with promising results. Cancer cells, particularly ...

The appearance and behaviour of cells are determined by the genes expressed in that cell. The abnormal behaviour of cancer cells can thus be explained by invoking quantitative and/or qualitative ...

The researchers discovered that combining venetoclax with a drug called 5-azacytidine significantly increased its effectiveness across many MM cell lines, indicating a broader potential patient ...

Van Andel Institute Chief Scientific Officer Peter A. Jones, Ph.D., D.Sc. (hon), has been elected to the National Academy of ...

“This approach opens new therapeutic avenues by attacking cancer’s altered metabolism, offering hope for more effective treatments.” By combining CB-839 with azacytidine, a drug that kills rapidly ...

Enrollment on track in Phase 2 portion of PYNNACLE clinical trial evaluating rezatapopt as monotherapy in patients with TP53 Y220C and KRAS ...

Even if you are receiving chemotherapy for MDS or in preparation for a stem cell transplant, you will also receive supportive care. The US Food and Drug Administration approved 5-azacytidine for the ...

When resistance to or failure of hypomethylating agents (HMAs) occurs in acute myeloid leukemia (AML), depleting a ligase ...