Figure 1: Deletion of exon 11 of Brca1 from mouse germ line. Figure 4: Effects of Brca1-Δ11 mutation on gene expression, tumorigenesis, cell survival and proliferation, and G 1 –S cell cycle ...

Yet women with one harmful BRCA1 mutation are far more likely to develop breast cancer—a risk traditionally explained by a ...

Whereas functional loss of BRCA1 or BRCA2 can lead to an accumulation ... In contrast, oncogenic 'driver' mutations such as BCR-ABL are important not only for the initiation of disease, but ...

A new study led by Harvard Medical School researchers shed new light on how even a single defective copy of the ...

Pharmacogenomics. 2012;13(13):1523-1535. 5-year survival for stage III and IV (%): carriers, 38.1; noncarriers, 24.5 Median survival: p = 0.002 5-year survival for stage III and IV: p < 0.001 [46 ...

Several studies have been completed looking at the effect of BPO in women at high risk of developing ovarian cancer because of family history or because of being mutation carriers of either BRCA1 ...

Results of a cohort of patients with various solid tumors with germline or somatic BRCA1 and 2 mutations treated with talazoparib are reported. BRCA1 is involved in both non homologous end joining, ...

A new study in mice explains how even a single faulty copy of the BRCA1 gene can fuel tumor growth. The findings suggest the dominant “two-hit” hypothesis of cancer development may not tell the full ...

Individuals with inherited mutations in BRCA1 are predisposed to breast, ovarian and other cancers. BRCA1 helps prevent cancer by repairing damaged DNA, but how it does so remains to be determined.

Genetic mutations can increase cancer risk. BRCA, Lynch syndrome, and TP53 mutations are linked to specific cancers. Regular ...

BRCA mutations are inextricably linked with breasts, but they can also lead to cancer in the pancreas, the prostate, and ...

BC Cancer, Harvard Medical School and Memorial Sloan Kettering Cancer Center (MSK) have pinpointed what could be the early ...