Yet women with one harmful BRCA1 mutation are far more likely to develop breast cancer—a risk traditionally explained by a ...

A new study led by Harvard Medical School researchers shed new light on how even a single defective copy of the ...

A new study in mice explains how even a single faulty copy of the BRCA1 gene can fuel tumor growth. The findings suggest the dominant “two-hit” hypothesis of cancer development may not tell the full ...

BRCA mutations are inextricably linked with breasts, but they can also lead to cancer in the pancreas, the prostate, and ...

Genetic mutations can increase cancer risk. BRCA, Lynch syndrome, and TP53 mutations are linked to specific cancers. Regular ...

Ask yourself how the genetic test results may affect your life. If the results come back positive, will you take steps to ...

BC Cancer, Harvard Medical School and Memorial Sloan Kettering Cancer Center (MSK) have pinpointed what could be the early ...

Ovarian cancer vaccines are under development, but none are ready for primetime. There are no screening tools for ovarian ...

Pharmacogenomics. 2012;13(13):1523-1535. 5-year survival for stage III and IV (%): carriers, 38.1; noncarriers, 24.5 Median survival: p = 0.002 5-year survival for stage III and IV: p < 0.001 [46 ...

Figure 1: Deletion of exon 11 of Brca1 from mouse germ line. Figure 4: Effects of Brca1-Δ11 mutation on gene expression, tumorigenesis, cell survival and proliferation, and G 1 –S cell cycle ...

Several studies have been completed looking at the effect of BPO in women at high risk of developing ovarian cancer because of family history or because of being mutation carriers of either BRCA1 ...