69) and, notably, the co-stimulatory receptor CD80 (Ref. 70), which by interaction with its T-cell expressed ligand, CD28, has an important role in the B-cell–T-cell interactions that occur in ...
Candidate genes at this locus include those that encode the T cell costimulatory receptors, CD28 and CD152 (also called cytotoxic T lymphocyte antigen 4, or CTLA-4). Figure 1: Structures and ...
The National Academy of Medicine (NAM) today announced that Gordon Freeman and Arlene Sharpe are the recipients of the 2024 ...
[100] Once the Th2 polarization process is complete, IL-4 and IL-13 promote binding of costimulatory molecules (CD40 with CD40 ligands and CD80 or CD86 with CD28) on Th2 cells and B cells ...
During this process, the CD28-mediated co-stimulatory signal plays a central role ... by 4-1BBL express higher levels of immune co-stimulatory molecules (such as CD80, CD83, HLA-DR) compared to DCs ...
系统性红斑狼疮（Systemic Lupus Erythematosus, SLE）是一种系统性自身免疫病，以全身多系统多脏器受累、反复的复发与缓解、体内存在大量自身抗体为主要临床特点，如不及时治疗，会造成受累脏器的不可逆损害，最终导致患者死亡。
Over the last decade, TNF-α antagonists became the most powerful tools for controlling patient suffering from a number of rheumatic diseases. Infliximab, etanercept and adalimumab can induce ...
CD80+CD86+“M1极化（M1-polarized）”肿瘤相关巨噬 ... 靶向在多种免疫细胞上表达的共刺激分子4-1BB、CD28、BTLA、GITR和CD27的药物正在进行中。以4-1BB激动剂为例，第一代有两个代表性产品：urelumab和 ...
Some results have been hidden because they may be inaccessible to you
Show inaccessible results
Feedback