In the past 5–10 years there has been a growing trend for substituting conventional 5-fluorouracil with the oral prodrug of 5-fluorouracil, capecitabine, in chemotherapy regimens. This regimen ...

High-dose chemotherapy (HDC) can have cardiotoxic effects. Experimental data have indi-cated that angiotensin-converting-enzyme inhibitors could prevent cardiotoxicity following HDC. Now ...

Analyses found lower cardiotoxicity from triplet mHSPC therapy involving darolutamide vs abiraterone/prednisone in addition to ADT and docetaxel. Triplet therapy ...

Herrmann et al. compared the safety and efficacy of gemcitabine plus capecitabine (GemCap) with that of gemcitabine monotherapy in patients with pancreatic cancer. This phase III trial included ...

Strong preclinical evidence of Annamycin's potential for treating pancreatic cancer presented at AACR expands collaboration ...

During the first cycle of capecitabine development, three concomitant drugs were found to affect 5-FU clearance. [5] Paracetamol and morphine increased 5-FU clearance by 26% and 41%, respectively ...