The principal biochemical feature of rodents is the presence of carboxylesterase in blood plasma, which is a target for OPs and can greatly distort their specific effects. The present study was ...

This three-step pathway involves the enzymes carboxylesterase, cytidine deaminase and thymidine phosphorylase (Figure 1), all of which are expressed in hepatic and tumor tissue. In particular the ...

Biotransformation of methylphenidate by the carboxylesterase CES1A1 is rapid and extensive leading to the main, de-esterified metabolite α-phenyl-2-piperidine acetic acid (ritalinic acid), which ...

Circ Cardiovasc Genet. 2013 Apr;6(2):184-92. doi: 10.1161/CIRCGENETICS.111.964627. Epub 2013 Feb 5. The functional G143E variant of carboxylesterase 1 is associated with increased clopidogrel active ...

AIH type 3 is serologically defined by the presence of SLA/LP autoantibodies. However, 74% of patients also have other serological markers of autoimmunity, including SMA and AMA. AIH type 3 has a ...