was also associated with the DISC in cells stimulated to undergo apoptosis in a way that is dependent on CUL3. Although p62 acts downstream of caspase-8 ubiquitination, it is important for its ...

New research has identified the Rho GTPase target ROCK-I as being cleaved by caspases during apoptosis. ROCK-I is known to stimulate actomyosin-based contractility. Once cleaved, ROCK-I is ...

Scientists use cell death, whether by apoptosis or necrosis, to evaluate the toxicity or effectiveness of substances of interest, including potential therapeutic agents. For example, researchers will ...