Errors in these checkpoints can have catastrophic consequences, including cell death or the unrestrained growth that is cancer. Another important checkpoint takes place later in the cell cycle ...

The antibody that binds to this epitope (a specific part of the death receptor), essentially represents the kill switch for ...

An international research team has uncovered a new mechanism crucial to the production of cellular proteins. When this ...

Researchers at the University of Michigan Rogel Cancer Center have discovered a key reason why some cancers do not respond to ...

Researchers from the National Defense Medical Center in Taiwan have identified an increased risk of psoriasis in patients ...

This immune imbalance contributed to evasion of immune destruction and limited the efficacy of programmed cell death protein 1 (PD-1) blockade. Dual checkpoint blockade reprogrammed the immune ...

Abatacept reduces immune activity by enhancing the activity of CTLA-4, a checkpoint receptor that tamps down T cell activation. By turning off immune responses through this mechanism, Abatacept ...

The immune system is a major target for cancer treatments. Immune checkpoint inhibitors and CAR-T cell therapy can ...