This effect is mediated by the binding of activated glucocorticoid receptors to two 5' promoter-negative glucocorticoid response elements on the ACTH precursor gene pro-opiomelanocortin.

These agents are thought to reduce bone mass via induction of apoptosis and/or suppression of osteoblast differentiation, effects that are mediated by the glucocorticoid receptor (GR), a nuclear ...

In addition to its physiological function, synthetic derivatives of cortisol are also used as anti-inflammatory drugs. In the ...

The most common cause of exogenous Cushing syndrome is the long-term use of high dose cortisol-like medications called glucocorticoids. This condition usually goes away once a person stops taking ...

Mitotane reduces cortisol synthesis through the inhibition ... for improvement in glucose control is desirable. Glucocorticoid receptor antagonists (mifepristone) and somatostatin receptor ...

There is evidence that lower doses may be equally effective, especially in patients with less severe edema. [10] If beneficial, neurological improvement can be expected within 48 h with this ...

Reduced cortisol levels is one such benefit. It is due to the presence of catechins, a group of antioxidants that bind to ...

Cortisol is the body’s main stress hormone. According to hundreds of clips on social media, an excess of stress – and, by extension, an excess of cortisol – results in a round, puffy face.

Roach: I have been diagnosed with low cortisol and put on 15-mg hydrocortisone ... (Cortisone is a type of steroid called a glucocorticoid.) This condition has many underlying causes, but the ...

MC2R encodes the receptor in the adrenal cells that interact with ACTH. If the receptor is faulty, the message from the pituitary gland can not enter the adrenals cells and therefore no cortisol is ...