This effect is mediated by the binding of activated glucocorticoid receptors to two 5' promoter-negative glucocorticoid response elements on the ACTH precursor gene pro-opiomelanocortin.

In addition to its physiological function, synthetic derivatives of cortisol are also used as anti-inflammatory drugs. In the ...

These agents are thought to reduce bone mass via induction of apoptosis and/or suppression of osteoblast differentiation, effects that are mediated by the glucocorticoid receptor (GR), a nuclear ...

The most common cause of exogenous Cushing syndrome is the long-term use of high dose cortisol-like medications called glucocorticoids. This condition usually goes away once a person stops taking ...

Extraglandular Sources of Cortisol Production & Metabolism & Their Role in the Pathophysiology of PCOS The regulation of peripheral cortisol metabolism, particularly in the visceral fat tissues ...

A subset of women with polycystic ovary syndrome (PCOS) may present adrenal hyperandrogenesis, although adrenal cortisol production rate appears to be normal. Obesity is often associated with PCOS ...

Reduced cortisol levels is one such benefit. It is due to the presence of catechins, a group of antioxidants that bind to ...

Cortisol is the body’s main stress hormone. According to hundreds of clips on social media, an excess of stress – and, by extension, an excess of cortisol – results in a round, puffy face.

Roach: I have been diagnosed with low cortisol and put on 15-mg hydrocortisone ... (Cortisone is a type of steroid called a glucocorticoid.) This condition has many underlying causes, but the ...

MC2R encodes the receptor in the adrenal cells that interact with ACTH. If the receptor is faulty, the message from the pituitary gland can not enter the adrenals cells and therefore no cortisol is ...