It is unclear whether these beneficial effects are due solely to aldosterone blockade, as MR has a similar affinity for cortisol. We examined the relationships between plasma and urinary steroid ...

Both cortisol and aldosterone are potent activators of renal MCRs. In vitro, cortisol is a tenfold more potent activator of the MCR than aldosterone. In the kidney, 11β-hydroxysteroid ...

Adrenal glands can also be impaired if there is a disorder in the pituitary gland, as it signals the adrenals to make certain ...

Addison's disease, also called primary adrenal insufficiency, is a chronic condition in which the adrenal glands fail to produce enough cortisol and aldosterone. Cortisol is the body's main stress ...