How do DNA repair mechanisms detect and repair damaged DNA, and what happens when they fail? Defects in DNA repair underlie a number of human genetic diseases that affect a wide variety of body ...

This important work advances our understanding of DNA methylation and its consequences for susceptibility to DNA damage. This work presents evidence that DNA methylation can accentuate the genomic ...

Bacteria frequently encounter adverse environmental conditions, such as nutrient scarcity and antibiotic exposure, which can ...

multiple cellular DNA repair mechanisms exist to remove damaged regions of chromosomes to prevent these potentially deleterious effects. Inhibition of ATM in corneal endothelial cells restores DNA ...

The excision repair pathway is the predominant, and perhaps universal, mechanism for the maintenance of genomic integrity. This pathway is responsible for repairing a wide variety of DNA lesions ...

Other studies uncovered related mechanisms during DNA repair in flies and other organisms. However, scientists exploring similar mechanisms in human and other mammalian cells reported little to no ...

Bacteria frequently encounter adverse environmental conditions, such as nutrient scarcity and antibiotic exposure, which can induce DNA damage ...

Other studies uncovered related mechanisms during DNA repair in flies and other organisms. However, scientists exploring ...

Any recent text book of neurology will list at least 200 neurological disorders, with diverse etiologies and genetic characteristics. A number of these disorders have a definitive link to an ...

POLK expression in neurons and report an important observation that POLK exhibits an age-dependent change in subcellular localization, from the nucleus in young tissue to the cytoplasm in old tissue.

Previously, scientists have discovered that they possess robust DNA repair mechanisms and a unique protein called Dsup, which ...

Reseachers from WEHI (Melbourne, Australia) have found a new way to predict a subset of patients who are likely to become ...