DNA damage and repair refers to the creation and correction of DNA lesions that threaten genome integrity. Because DNA replication errors or environmental agents that damage DNA can introduce ...

Telomere shortening and DNA damage play crucial roles in aging, a multifaceted biological phenomenon characterized by a ...

“DNA repair and autophagy are distinct biological ... “Mechanistically, the autophagy receptor TEX264 acts as a TOP1cc sensor at DNA replication forks, triggering TOP1cc processing by the ...

Their study has shown how non-coding DNA can get in the way of the replication and repair of our genome, potentially allowing mutations to accumulate. It has been previously found that non-coding or ...

Researchers at the University of Toronto have discovered a DNA repair mechanism that advances ... and through internal processes such as DNA replication. They are one of the most serious types ...

During DNA replication, special enzymes move up along the DNA ladder, unzipping the molecule as it moves along. New nucleotides move in to each side of the unzipped ladder. The bases on these ...

Researchers hope to plan clinical trials of 5-fluorouracil with drugs that would enhance its RNA-damaging effects and kill ...

一项新的研究表明在婴儿出生后的第一年里，母乳不仅能提供营养，还能调节婴儿的微生物组合（即微生物组），从而降低孩子患哮喘的风险。相关研究结果发表在2024年9月19日的 Cell 期刊上，论文标题为 “Microbial colonization ...

When not undergoing replication, DNA molecules float freely within the cytoplasm of a cell. This makes them available to the accessory molecules that organize and repair DNA. However, when cells are ...

Scientists have discovered why certain organs, like the liver, age faster than others. A research team from the University of ...

as well as for DNA replication, repair, and segregation to daughter cells. Nucleosomes are repetitive building blocks introduced in the monotonous linear structure of double-helical DNA.

During DNA replication, the double helix unwinds ... resulting in a point mutation. Cells have evolved various DNA repair mechanisms to correct such mutations. One such mechanism is base excision ...