LTβR –induced non-canonical NFκB activation in various stromal subsets within the SLOs is obligatory for the full differentiation of marginal reticular cells (MRC), follicular dendritic cells ...

Immuno-oncology is a promising treatment approach that stimulates the immune system to detect and attack cancer cells. “We’ve seen an initial wave of checkpoint inhibitors and systemic agents ...

Dendritic cells (DCs) actively participate in maintaining this balance. Under steady-state conditions, DCs remain in an immature state and do not mount an immune response against circulating self ...

Some patients being treated with immune checkpoint inhibitors, a type of cancer immunotherapy, develop a dangerous form of heart inflammation called myocarditis. Researchers have now uncovered the ...

Stromal cell therapy is a promising frontier in lupus research, especially for people whose lupus doesn’t respond to other treatments (called refractory lupus). We were the first lupus organization in ...

Dr. Smythies earned her B.Sc. (Hons), A.K.C. at Kings College, London University, England and her Ph.D. at Wye College, London University. She did postdoctoral fellowships in the Department of ...

During pregnancy, the maternal immune system must engage in a fine balancing act: maintaining tolerance to the fetal allograft while restoring innate and adaptive immune mechanisms for protection ...

What are germ cell and sex cord stromal cells? Germ cells and sex cord stromal cells form when a fetus (baby) is developing. A fetus is made from a sperm cell and an egg cell. Germ cell tumors (GCTs) ...

at the Max Planck Institute of Molecular Physiology identified a chemical substance that proved to be highly effective against drug-resistant gastrointestinal stromal tumor cells in preclinical ...

According to many experts, we may soon find ourselves using fuel cells to generate electrical power for all sorts of objects we use every day. A fuel cell is a device that uses a source of fuel ...

Cells are the smallest unit of life and the building blocks for all organisms. Each component of a cell has its own function. Animal and plant cells differ and they have similarities. Nucleus ...