Adherens junctions (red dots) join the actin filaments of neighboring cells together. Desmosomes are even stronger connections that join the intermediate filaments of neighboring cells.

Scientists discovered that many people with ARVC have a genetic mutation in special proteins called desmosomes, which connect ...

In particular, adaptor complexes bind adherens junctions to cytoskeletal actin, and other adaptor complexes bind desmosomes to intermediate filaments. Both of these types of junctional complexes ...

Pemphigus is an autoimmune bullous disease, in which autoantibodies react with the cell–cell adhesion structures, desmosomes, causing blisters and erosions on the oral mucosa and skin.

Receptor Protein Tyrosine Phosphatases, cell-cell adhesion and signal transduction: We are studying the role of receptor protein tyrosine phosphatases (RPTPs) in signals transduced upon cell-cell ...

With mutated desmosomes, normal levels of myocardial wall stress lead to cellular disruption and (fibro-fatty) repair, ending in familial ARVC. But we propose that a similar phenotype may develop when ...

Researchers have demonstrated that a single treatment with Er laser will lead to long-term remission from Hailey-Hailey ...

Pemphigus is a rare autoimmune blistering disease involving the skin and mucous epithelia. It is clinically characterized by flaccid blisters and erosions (Figure 1) and, if left untreated, could ...