Endothelial cells are major participants in and regulators of inflammatory reactions. Resting endothelial cells prevent coagulation, control blood flow and passage of proteins from blood into ...

Figure 1: α v β 3 as a mediator of antiangiogenic regulators. Figure 2: Trans-dominant inhibition of proangiogenic integrins. In presenting these models for negative regulation by α v integrins ...

Atherosclerosis involves multiple processes including endothelial dysfunction ... to other cellular processes such as inflammation, apoptosis and matrix alterations. The contribution of vascular ...

Here I developed a platform for functional screening of flow-responsive apoptotic regulators in zebrafish. I subsequently used this model to identify mechanoreceptors regulating endothelial apoptosis ...

The quality and quantity of the ceramide response, in combination with other signals, determines whether adaptation or apoptosis ensues. This pathway is evolutionarily conserved ... Gemcitabine kills ...

GlobalData’s report assesses the drugs in the Angiopoietin 2 pipeline by therapy areas, indications, stages, MoA, RoA, molecule type and the key players in the development pipeline.

Doxazosin remains a commonly used antihypertensive medication, although its use has been tainted by recent findings from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack ...

Disturbed blood flow generates frictional forces (shear stress) that trigger pathophysiological changes in endothelial cells that promote atherosclerosis initiation and the progression of plaques into ...

Epigenetic, bioelectromic, synaptic, and senolytic interventions could rejuvenate cells and counter the effects of aging.

apoptosis (programmed cell death), and various environmental factors. A more severe form of macular degeneration, neovascular or wet AMD, sets on much more rapidly and can lead to complete central ...

By Dr. Sanchari Sinha Dutta, Ph.D. Discover how scientists have uncovered the links between inflammatory proteins and ...

13 However, the phenotypes of these cells are yet to be fully characterised. Apoptosis pathways have also been described as an important signalling cascade implicated in the biology of Achilles ...