The expression of many eukaryotic genes is regulated at the level of translation initiation. The first step in the initiation process is binding of the small ribosomal subunit (40S) to the mRNA.

How does the cell convert DNA into working proteins? The process of translation can be seen as the decoding of instructions for making proteins, involving mRNA in transcription as well as tRNA.

The Merrick laboratory seeks to identify all of the eukaryotic translation initiation factors and determine their sequential utilization ... “Ternatin and improved synthetic variants kill cancer cells ...