Cells send electrical impulses throughout the body, but electrophysiologists struggled to tune into these signals until the ...

Our team has conducted the first genome-wide CRISPR screens to systematically identify new regulators of regulated exocytosis—a type of vesicle fusion—in mammalian cells. These screens revealed a ...

In secretory cells such as gonadotropes, the cytoplasmic face of the plasma membrane is associated with a dense meshwork of actin filaments (termed cortical actin) and actin binding proteins that play ...

MPXV enters host cells through attachment and fusion, with MVs typically released upon cell lysis and EVs exiting cells via exocytosis. Key viral proteins, homologous to those of the vaccinia ...

Protein contact dermatitis is an allergic skin reaction induced principally by proteins of either animal or plant origin. The clinical presentation is that of a chronic dermatitis, and it is often ...

They are capable of strong NK cell lysis of sensitive target cells. NK 3.3 cells have been shown to kill by both perforin/granzyme mediated granule exocytosis and by Fas-mediated killing. In addition, ...

The role of ITSN1, Intersectin-1, is to activate CDC42, a small Rho GTPase involved in the growth and maintenance of dopaminergic neurons and the regulation of vesicle exocytosis of α-synuclein ...

MBB 430-3 Mechanisms of Secretory Transportoffered Spring 2015 Analysis of mechanisms of protein, lipid, and nucleic acid delivery and transport within cells; processes of protein targeting, ...

Exocytosis of secretory vesicles is required for cellular growth, cellular division and cell–cell communication. Lee et al. reveal that the exocyst tethering complex has stimulatory roles in ...

This manuscript describes the impact of modulating signaling by a key regulatory enzyme, Dual Leucine Zipper Kinase (DLK), on hippocampal neurons. The results are interesting and will be important for ...