The Fanconi Anemia pathway, named after a cancer-predisposition syndrome, is essential for the repair of DNA-interstrand crosslinks (ICLs). The pathway consists of 22 FA complementation group proteins ...

近日，一篇发表在国际杂志Cell上题为“The Fanconi anemia pathway induces chromothripsis and ecDNA-driven cancer drug resistance”的研究报告中，来自德克萨斯大学西南 ...

which is correlated with a functional FA pathway. Figure 1: Current view on the Fanconi anemia (FA) pathway of genome stabilization.

What is the connection between Fanconi anemia and breast cancer? It seems to be nuclear dots. Garcia-Higuera et al. 2 propose that a pathway that leads to the activation of FANCD2 is initiated by ...

"These findings could eventually lead to new strategies incorporating Fanconi anemia pathway inhibition with other drugs to combat the emergence of therapy-resistant cancer cells, which represents ...

Their hunt narrowed to a set of genes involved in the Fanconi anemia pathway—a DNA repair mechanism mutated in an eponymous ...

In the area of growth control, our recent work is focused on the mTOR pathway that controls multiple aspects of cell growth and homeostasis. Our work on genomic integrity ranges from the Fanconi ...

Their hunt narrowed to a set of genes involved in the Fanconi anemia pathway – a DNA repair mechanism mutated in an eponymous germline condition marked by severe anemia, bone marrow failure, cancer ...

Beyond cancer, understanding certain elements of the HIF pathway could permit researchers to study how to modify the body’s natural response to low oxygen in other diseases, such as anemia of ...

The importance of this is because the company may not have to go through an entire clinical pathway to receive ... the treatment of patients with Fanconi Anemia [FA]. The risk here is that there ...

Through the Pathways you will develop a deep knowledge base in a chosen topic and learn how different disciplines approach a similar line of study. Take ownership of your education by choosing topics ...