G蛋白偶联受体（G protein–coupled receptors GPCRs ... GPCR结合配体后，Gα亚基结合GTP，变为活跃状态，并与Gβγ复合物及GPCR分离。分离的Gα-鸟苷三磷酸 ...

Development of GGTase I inhibitors that demonstrate selectivity for monomeric versus heterotrimeric G proteins (such as ... end points may include RAS GTP levels, determination of CENPE, CENPF ...