Researchers used mitochondrial gene editing to model genetic disorders in mice, revealing profound impacts on brain function, metabolism, and thermoregulation.

Mouse mutagenesis phase II Knockout mouse mutagenesis. Gene targeting, also called knockout mouse technology, made it possible to conduct site-directed mutagenesis in a mammalian genome for the ...

to knockout and characterize all protein-coding genes in the mouse genome. Knocking out the activity of a gene provides valuable clues about what that gene normally does. However, creating and ...

Mitochondria possess their own DNA (mtDNA), which plays important roles in cellular respiration and energy consumption.

Animal models expressing loss-of-function mutations in mitochondrial DNA enable the investigation of mitochondrial gene function and related disorders. In a recent study, scientists from Korea ...

A minimum of 3 positive founders will be delivered. To produce CRISPR/cas9-mediated gene indels to generate knock-out mice or rats. The investigator will provide or purchase the CRISPR gRNA(s). TGEF ...

The research group led by Chinese Academician Jiazuan Ni (College of Life Sciences and Oceanography, Shenzhen University), ...

Both gene knockout and knock-in models are powerful tools widely used in biomedical research to gain important insights into ...

A Michigan State University researcher's new model for studying breast cancer could help scientists better understand why and ...

Researcher creates a groundbreaking genetic model for breast cancer, offering new insights and potential advances in ...