Because the effects of a polymorphism can be subtle and can vary according to genetic background, there are rigorous methodological challenges associated with determining the effect of a ...
Purpose. The effects of genetic polymorphisms on the pharmacokinetics of calcineurin inhibitors were examined. Pharmacogenetics examines the relationship between single-gene polymorphisms and the ...
2006;63(23):2340-2348. MDR1 (ABCB1) T-129C, C1236T, G2677(T,A), C3435T No difference observed for cyclosporine and any CYP3A5 polymorphism Wild-type carriers of MDR1 (ABCB1) 1236 had lower dose ...