引言三阴性乳腺癌（TNBC）约占所有侵袭性乳腺癌病例的 15% 至 20%，其特点在于缺乏雌激素受体（ER）、孕激素受体（PR）及人类表皮生长因子受体 2（HER2）的表达。TNBC ...

相关研究结果以 Fetal hypoxia exposure induced Hif1a activation and autophagy in adult ovary granulosa cells为题，于10月1日在生殖生物学国际期刊?Biology of Reproduction?以Article的形式在线发表 ...

Odds ratio (OR) with 95% confidence intervals (CIs) were calculated using fixed or random effects model incorporating inverse-variance-weighted method for relating HIF1A 1772 C/T polymorphism ...

Prolonged hypoxia and tissue damage from surgery play key roles in adhesion formation, at least in part by inducing the release of known fibrotic mediators such as HIF1a, TGF-β1, TGF-β2 ...

Developed 3MIC model simulates tumor microenvironments, enabling direct observation of ischemic effects on cancer cell invasiveness and drug resistance.

Accumulation of extracellular matrix (ECM) in liver fibrosis is associated with changes in protein abundance and composition depending upon etiology of the underlying liver disease. Current efforts to ...

In rats with increased sensitivity to hypoxia, doctors discovered a tendency to form pro-inflammatory macrophages. This is evidenced by the increased content of Hif1a and CCR7 proteins compared to the ...

A multigene signature can be used to guide decisions about adjuvant therapy in patients with triple-negative breast cancer, data suggest.