the fly's suite of Hox genes must be expressed in a precise way and at precise times. Gene switches such as Ubx make the initial decisions of which genes to turn on or off in different body ...
Hox genes and their relatives are involved in several developmental processes in diverse animals, but when did they first arise? The genome sequence of the sponge Amphimedon queenslandica shows ...
MLL1 is rearranged in patients with acute leukaemia and leads to the deregulated expression of HOX genes, among other changes. MLL1 interacts with a wide variety of proteins, and four recent ...
In fruit flies, for example, a malfunctioning body-plan gene can produce a fly with legs sprouting from where the antennae should be on the head. Or the fly has an extra set of wings -- or no ...