本病例由免疫点抑制剂治疗后引起免疫性心肌损伤，但由于cTnT和cTnI之间动力学差异，造成结果不一致，引起临床困惑。经过和临床密切沟通，多方查证，找到两者差异的原因，并协助医生准确判断病情，及时处置化解风险。整个诊疗过程，从临床医生提出疑问，到细致分 ...

The team blocked Hsp70 proteins using laboratory compounds which have yet to be developed into clinical drugs. Drug development doesn’t happen overnight, and this research highlights the need to take ...

HSP70 are extremely flexible proteins (Fig. 3B), therefore a key challenge is to understand how the conformational flexibility of HSP70s affects ligand binding and how it can be exploited in inhibitor ...

This useful study by Gao et al identifies Hspa2 as a heterogeneous transcript in the early embryo and proposes a plausible mechanism showing interactions with Carm1. The authors propose that ...

Historically, most people started HIV treatment with two drugs from the NRTI class combined with either one NNRTI, one protease inhibitor or one integrase inhibitor – hence, ‘triple therapy’.

Methylation of HSP70 orchestrates its binding to and stabilization of BCL2 mRNA and renders ... Mechanisms and clinical activity of an EGFR and HER2 exon 20-selective kinase inhibitor in non-small ...

Rust preventatives and corrosion inhibitors are lubricants, greases, oils, or fluid additives that form a protective film or barrier to prevent the formation of rust or corrosion. They often have ...

Cancer growth blockers are also called cancer growth inhibitors. They are a type of targeted cancer drug. Our body makes chemicals called growth factors that control cell growth. Cancer growth ...

ASP-2138 is a bispecific antibody targeting CD3 and claudin 18.2 (CLDN18.2). It is administered through intravenous drip ...

How do PARP inhibitors work? PARP is a protein (enzyme) found in our cells, it stands for poly-ADP ribose polymerase. It helps damaged cells to repair themselves. As a cancer treatment, PARP ...