The answer lies in the molecular chaperone heat shock protein 90 (Hsp90), according to a recent report in Current Biology. ...Hsp90 inhibitors could induce a switch from yeast to filamentous ...

Molecular chaperones like HSP90 can promote folding of damaged proteins or dispatch them for proteasomal degradation; chaperones also can counteract apoptosis. The two new studies should ease ...

We determined the structure and function of Heat Shock Protein 90 (Hsp90), a molecular chaperone which is critical for the growth and survival of cancer cells. Photo: Jan Chlebik for the ICR We worked ...

Cell cycle and apoptosis were determined by flow cytometry ... Hsing J, Mcconkey D and Logsdon C. GRP78 and HSP90 are overexpressed in pancreatic cancer. Cancer Res 2007; 67: 708. 29. Chiu CC and ...

Cleavage of Caspase 3, PARP1 and HSP90, as well as increased Annexin V positivity, suggests potent activation of apoptosis by this two-drug combination; increased levels of γ-H2AX, P-CHK1 (S317), ...

Also highlighted here are the MCV proteins that inhibit apoptosis, inflammation and immune cell recruitment or that induce cellular proliferation, with discussion as to how these proteins dampen ...

The Potential of Hsp90 in Targeting Pathological Pathways in Cardiac Diseases ... Lachke, S.A., Duncan, M.K. Beta1-integrin deletion from the lens activates cellular stress responses leading to ...

Using an amino acid depleted media, we can induce autophagy without apoptosis during myogenesis in vitro. We have characterized the histone methylation profiles affected by this cell phenotype switch ...

Using an amino acid depleted media, we can induce autophagy without apoptosis during myogenesis in vitro. We have characterized the histone methylation profiles affected by this cell phenotype switch ...