Hsp90 has a role in nearly every cellular function ... Trap1 translocated to the mitochondria. Inhibition of Trap1 at this stage markedly affected the prestarvation response and inhibited ...

Surprisingly, Kang et al. 2 found that HSP90 (whether HSP90α, HSP90β or both is not clear) localized to the mitochondria of tumor cells but not normal cells. Similarly, TRAP-1 was more abundant ...

发烧和身体酸痛作为生物长期进化以来产生的免疫系统外挂，保障身体及时对内外环境变化做出反应。下丘脑的体温调节为免疫系统击溃来犯之敌提供了坚实的后勤保障，而参与作战的诸多免疫细胞，一部分在对抗病原菌入侵时牺牲，一部分也会在大战落幕后结束生命，这不仅能够防 ...

We determined the structure and function of Heat Shock Protein 90 (Hsp90), a molecular chaperone which is critical for the growth and survival of cancer cells. Photo: Jan Chlebik for the ICR We worked ...

Many of us remember from high school biology class that mitochondria are the cell’s “power plants.” These small kidney-bean-shaped structures are what convert nutrients from food into ATP ...

This valuable study reveals extensive binding of eukaryotic translation initiation factor 3 (eIF3) to the 3' untranslated regions (UTRs) of efficiently translated mRNAs in human pluripotent stem ...

A novel curcumin derivative, C210, activates the Epstein–Barr virus (EBV) lytic cycle without producing infectious virions by disrupting HSP90. This discovery opens avenues for safer EBV ...

Animal and plant cells differ and they have similarities. Nucleus, cell membrane, cytoplasm and mitochondria are four cell components that are found in both animal and plant cells. All life on ...

Future Virology. 2013;8(6):561-573. Apoptosis is an effective mechanism to destroy virus-infected cells. Central to this process is the interaction of FADD and procaspase-8. [58] During TNFR-1 ...

The middle piece is packed with mitochondria to release energy needed to swim and fertilise the egg. The tail enables the sperm to swim. The nerve cell is extended, so that nerves can run to and ...

The group has expertise in researching inhibitors of HSP90, Chk1, ATR and DNA-PK and most of the recent work has focussed ... Gene therapy-mediated silencing of connective tissue growth factor (CTGF) ...

A novel curcumin derivative, C210, activates the Epstein–Barr virus (EBV) lytic cycle without producing infectious virions by disrupting HSP90. This discovery opens avenues for safer EBV ...