Although GIP also exerts potent incretin-like effects on β cells in healthy individuals, the actions of GIP are impaired in patients with diabetes mellitus, which limits the possibilities of its ...
We aimed to investigate whether the reduced incretin effect observed in patients with type 2 diabetes is a primary event in the pathogenesis of type 2 diabetes or a consequence of the diabetic state.
Incretin therapies based on GLP-1 receptor agonism aid in the loss of weight in obesity, but a relevant part of this loss (25%-40%) is attributed to loss of lean muscle mass, which raises the risk of ...