Further, in a mouse model of TEN, oral administration of tofacitinib, or the JAK1 and JAK2 inhibitor baricitinib, reduced STAT1 phosphorylation and disease severity, decreased keratinocyte death ...
Upadacitinib will face two main JAK inhibitor competitors – Eli Lilly’s Olumiant and Pfizer’s Xeljanz. Despite excitement surrounding the class, though, these treatments all face a complex ...