Leflunomide is the only nonbiologic DMARD developed specifically for the treatment of RA. It is an isoxazole derivative and its active metabolite, teriflunomide (formerly known as A77 1726), acts ...

Researchers in the Netherlands therefore evaluated another DMARD, leflunomide, effective in psoriatic arthritis and rheumatoid arthritris, in a double-blind, randomized, placebo-controlled trial ...

This study investigated, for the first time, the efficacy and safety profile of leflunomide 20mg daily in ambulatory RA patients in typical settings. This is of importance, as the existing body of ...

Leflunomide is largely considered to be a second-line treatment option for rheumatoid arthritis (RA). Those who fail to respond, tend to progress to treatment with expensive biological agents ...