Recent studies suggest that these granules can "hitch a ride" from lysosome-related vesicles, membrane-bound structures in cells that share common characteristics with lysosomes. Researchers at ...

Amidst the wide variety of glycan modifications that are carried out in the Golgi apparatus, the addition of mannose 6-phosphate (M6P) to the N-linked glycans of lysosome-resident hydrolase enzymes ...

In the study titled "Lysophagy protects against propagation of α-synuclein aggregation through ruptured lysosomal vesicles," published in Proceedings of the National Academy of Sciences ...

The completed vesicle fuses with the vacuole, the yeast analogue of the mammalian lysosome. The larger size of the vacuole allows the release of the inner single-membrane compartment of the Cvt ...

Hobbling lysosomal function with a suite of inhibitors ramped up ... These ARCs were likely microglia, and they contained amyloid filaments within intracellular vesicles. At the time, the authors ...