The degree of complexity and crossover within MAPK signaling, and also shifts in pathways such as nuclear factor κB signaling, could also explain the modest effect of p38 inhibitors. The p38α ...

In the search for the cause of CPAM, the research team pursued the following hypothesis: Variants in cancer-associated genes of the so-called RAS-MAPK signaling pathway, which occur in the lung ...

The following is a summary of “Cell-integrated serum-induced signalling patterns can differentiate between hand and knee osteoarthritis patients,” published in the November 2024 issue of Hematology by ...

These pathways include nuclear factor- B, p38 mitogen-activated protein kinase, NH 2-terminal Jun kinases/stress-activated protein kinases, hexosamines, and others. In addition, there is evidence ...

SOS1 is a guanine nucleotide exchange factor (GEF) that activates KRAS, and recent preclinical studies have demonstrated that combining KRAS and EGFR inhibitors with SOS1 inhibitors can overcome ...

Verastem Oncology (Nasdaq: VSTM), a biopharmaceutical company committed to advancing new medicines for patients with cancer, ...