Discover Ono Pharmaceutical's groundbreaking patent for autophagy-inhibiting compounds, targeting various cancers with innovative MEK inhibitors like selumetinib.

近年来随着治疗靶点的发现和新型靶向药物的不断研发，肿瘤治疗已步入精准治疗新时代。近日，2024 年世界肺癌大会（WCLC）和欧洲肿瘤内科学会（ESMO）年会陆续召开，带来肿瘤领域最新前沿进展。会议中，针对 BRAF、MET 14 ...

Atriva Therapeutics is starting a phase 2 trial of its MEK inhibitor ATR-002 in patients with coronavirus infections, saying the drug could help prevent patients progressing to critical-stage ...

Geoffrey D. Young, MD, PhD, FACS, discussed the many advances in thyroid cancer management and treatment, highlighting what a ...

MEK Inhibitor-Based Treatments and FDA Approval of Selumetinib (Koselugo) Several clinical trials have investigated the effectiveness of drugs called MEK inhibitors as potential treatments for ...

根据在FGFR2 融合+ ICC 细胞中抑制 FGFR后观察到的代谢可塑性，我们接下来探索了针对新出现的代谢弱点提高疗效的可能性。为此，我们测试了联合抑制FGFR和线粒体氧化代谢的效果。ONC212是一种对线粒体蛋白质量控制至关重要的ClpP蛋白酶激动剂，ONC212增强了FGFRi 在ICC13-7 和ICC21 细胞中的疗效，还研究了降低葡萄糖条件对这些反应的影响发，现，ONC212与 ...

Neoadjuvant therapy is an essential part of high-risk stage III resectable melanoma management, with combination ...

相关研究结果于2024年8月5日在线发表在EMBO Reports期刊上，论文标题为“Identification of resistance mechanisms to small-molecule inhibition ... MAPK 激酶 MEK 能协同 ...

Researchers at the University of Massachusetts Amherst and UMass Chan Medical School have demonstrated in mice a new method ...

Ruscetti’s previous research had demonstrated that two cancer drugs, the MEK inhibitor trametinib and CDK4/6 inhibitor palbociclib (T/P in combination), can promote blood vessel development ...