Kangbaida (Sichuan) Biotechnology Co. Ltd. has disclosed proteolysis targeting chimeras (PROTACs) comprising a cereblon (CRBN) ligand coupled to a mitogen-activated protein kinase kinase kinase kinase ...

One possibility is that in an attempt to overcome the inhibition within the metabolic insulin-signaling pathway, hyperinsulinemia may continue to stimulate the mitogenic insulin-signaling pathway ...

HMGB1's interactions with its primary receptors, RAGE and TLR4, are essential to its role in liver disease. Upon binding, ...

Single-cell analysis of CML patients bone marrow at diagnosis reveals coexistence of CD26-CD35+ healthy stem cells and CD26+CD35- CML stem cells, and how the ratio between these impacts TKI response.

They zoomed in on individual cells and studied them like never before, creating a map of the thousands of proteins driving this deadly reaction ... We identified a striking hyperactivation of the ...

The NDA was submitted under the FDA's accelerated approval pathway, with Verastem requesting a priority review. If the FDA ...

Their findings, which were published in Science Advances, also offer new insights into 2'3'-cGAMP's role in cell migration and how the newly identified 2'3'-cGAMP/Rab18/FosB signaling pathway ...

In our latest joint report – National Nature-positive pathways to guide policy and private sector action, WWF-UK and our partner Aviva outline the case for the development of government-endorsed ...

Mapping cell types in MS lesions reveals unique tissue niches and interactions, offering insights into the molecular drivers of multiple sclerosis progression.

DHA, PUFA, and SFA promote GnRH mRNA expression. Palmitate disrupts hypothalamic function in GnRH neurons by regulating spexin (SPX) and its receptors, galanin receptor 2 (GALR2) and galanin receptor ...

The Buffalo Bills select International Pathway Program offensive guard Travis Clayton in Round 7 of the 2024 NFL Draft with the No. 221 overall pick (via a trade with the Kansas City Chiefs).

However, this doesn’t have to be the case for your business. By building strong career pathways and offering meaningful training programs, you can retain top talent and help them thrive within ...