One must hypothesize ineffective megakaryocytic function in these cases. It is recognized that these cases will be difficult to understand until methods for quantitating megakaryocyte number and ...

Ph.D./M.S. Electrical & Computer Engineering, University of California, Santa Barbara B.S. Electrical & Computer Engineering, University of California, Santa Barbara Neda Bagheri directs the Modeling ...

GATA1 mutations, in conjunction with trisomy 21, increase the number of megakaryocytic progenitor cells, impede the terminal maturation of megakaryocytes, and cause leukemia. Trisomy 21 alters ...

To summarize, mechanisms responsible for the early suppression of megakaryocytic and erythroid development, for the generation of FLT3 hi VCAM1 − LSK cells and for the initiation of ...

Figure 2: Histology of a bone marrow biopsy sample after initial immunosupporessive therapy, showing megakaryocytic and erythroid precursor aplasia. The patient received a cycle of intravenous ...

KEY POINTS A 22-year-old White man presented to the emergency department with a 2-month history of progressive fatigue, intermittent abdominal pain, constipation, and dyspnea. He had gained 27 kg over ...