Epigenetics, the study of changes in gene function that do not involve alterations to the DNA sequence, plays a pivotal role ...

Examples of these include acetylation, acylation, glycosylation, methylation, sulfation and ubiquitination, among others. Much of recent research has also focused on histones, where PTMs are ...

Processes such as methylation and acetylation are reversible and may change quickly, rendering the genome a much more plastic entity than previously suspected. We may also understand this as the ...

The sequencing of the human genome at the turn of the 21st century was heralded as a monumental scientific achievement ...

A crucial discovery implicating epigenetics in learning and memory was the observation that neuronal activity can induce changes in DNA methylation 4. As one neuron communicates with another, ...

开发新型免疫靶点是提升免疫治疗效果的关键途径之一。徐瑞华教授研究团队在国际范围内率先提出了针对晚期胃癌的抗 CLDN18.2 治疗方案（免疫机制），为 CLDN18.2 阳性且 HER2 阴性的晚期胃癌患者开辟了新的治疗路径，显著改变了临床实践。此外 ...

Lower levels of histone post-translational modifications (methylation or acetylation) are associated with poor outcomes in prostate, lung, and kidney cancers. In contrast, higher levels of a ...

Methylation can lead to gene silencing by preventing transcription factors from binding to the promoter region of a gene. Histones are proteins that package and order DNA into structural units called ...

In fact, biological outcomes are often due to physical interactions between proteins that are so highly selective that seemingly minor chemical modifications (i.e. methylation, acetylation or ...

Histones are proteins that package and organize DNA into structural units called nucleosomes. Various chemical modifications can occur on the histone tails, such as acetylation, methylation, ...

Dr. Michael Pikaart has been working at Hope since 1999. Michael has membership in the American Society for Biochemistry and Molecular Biology, where he is involved in programs in education and ...