Another intriguing issue that will need to be further addressed is the question of why functional mitochondria are lost in the neuronal terminals more than in the cell body. The authors propose ...

This high energy demand for neuronal functions depends on the transport and precise distribution of mitochondria — the energy-generating cell organelles — in each neuron. Now, a study ...

Mitochondrial dysfunction in the brain can ... be a significant milestone for bipolar disorders.” Demystifying the neural circuits involved in bipolar disorders could also have implications ...

The research team further examined the physiological phenotypes of C. elegans with neuronal mitochondrial stress and observed an extended lifespan, enhanced pathogen resistance, and reduced lipid ...

It will give researchers access to the resources and chemistry expertise on compounds that could offer viable mitochondrial therapies for neurodegenerative diseases including motor neuron disease (MND ...

Many of us remember from high school biology class that mitochondria are the cell's "power plants." These small kidney-bean-shaped structures are what convert nutrients from food into ATP—the ...

Transforming growth factor-beta (TGF-β), a well-known morphogen, is recognized for its role in regulating growth and ...

New research uncovers how mitophagy, the cellular recycling of damaged mitochondria, changes dynamically in the aging ...

the axon - the long part of the motor neuron cell that connects to the muscle - was shorter than in healthy cells. And the movement of the mitochondria, which travel up and down the axons ...

Neuroscience research has increasingly focused on the role of autophagy in maintaining neuronal health and metabolism. Neurons, with their complex architecture and post-mitotic nature, require ...

inducing aberrant mitochondrial VCP accumulation, resulting in excessive mitophagy and subsequent neuronal cell death,” the team continued in their newly published work. As part of that 2016 ...

In the cell cultures that had been treated with the SAOs, there was reduced cell damage and lowered ROS levels in the mitochondria. The organelles also promoted cell regeneration via neural ...