The mitotic checkpoint is seldom lost or weakened in human tumours. Mitotic checkpoint overactivation is a more frequent observation in human tumours and is sufficient to generate CIN in vivo and ...
The subsequent breakdown of the nuclear envelope terminates prophase and initiates prometaphase, during which the chromosomes become attached to and positioned on the mitotic spindle as it forms.
(A) Histone staining images and OI-DIC density imaging of human living cells in the interphase (the phase between cell divisions, left) and mitotic phase (right). The bottom two rows are OI-DIC ...
"We are grateful to the FDA for their collaboration and review of our complete response package, which included a comprehensive safety assessment of the azenosertib program,” said Kimberly Blackwell, ...