Mouse models have significantly contributed to our understanding of liver fibrosis and its potential for regression. While no model perfectly replicates human disease, these experimental systems ...

Brigham and Women’s researchers uncover bile’s dynamic role in intestinal infection defense, revealing compositional changes ...

Liver-specific SMN1 gene therapy both improved liver functioning, and also reduced other SMA-like symptoms in a mouse model ...

Intestinal infections can change the composition of liver bile, leading to changes in immune function and gut bacteria, potentially helping fight off harmful bacteria .

A n antibody called bFKB1 improves liver disease and atherosclerosis in a mouse model of metabolic dysfunction-associated ...

Explore how E-selectin-targeted polymer-doxorubicin therapy induces regression in colorectal liver metastases.

According to Andrechek, while a genetically engineered mouse model can be artificially tweaked through injection to force cancer cells to go to organs like the liver or brain, his lab's newly ...

Researchers have identified a new axis of host defense by studying what happens during enteric infection -- a term that encompasses all types of intestinal infections including so called 'stomach flu.

The result was impressive: Not only did this therapy put a halt to further fibrosis, it seemed to reverse some of the stiff fibrotic scarring of the mouse liver tissue that had already taken place.

Accumulation of extracellular matrix (ECM) in liver fibrosis is associated with changes in protein abundance and composition depending upon etiology of the underlying liver disease. Current efforts to ...