I formulated the missing-self hypothesis for natural killer (NK) cell recognition in the autumn of 1981, while writing the last chapter of my doctoral thesis. In 1975, I had joined the Department ...

“We can engineer these NK cells to provide additional mechanisms or more activated cells that seem to be able to overcome those barriers.” Several challenges remain. Like CAR-T cells, NK cell ...

NK cells recognize cell-bound antibodies via CD16A (FcγRIIIA) to mediate antibody-dependent cellular cytotoxicity (ADCC). Potentiating therapeutic mAb-mediated CD16 activation of NK cells is an ...

Source: Sino Biological Inc. To mediate antibody-dependent cellular cytotoxicity (ADCC), NK cells recognize cell-bound antibodies via CD16A (FcγRIIIA). A new area of cancer immunotherapy is ...

a subset of NK cells bearing the activating Ly49H receptor, which specifically binds the viral glycoprotein m157, can proliferate 100-1000 fold in lymphoid and non-lymphoid organs following mouse ...

CAR-NK therapy involves modifying NK cells using ... “But importantly, you also activate memory T cells. With this, if you can activate the immune system, then, once you’ve stopped the ...

almost as if they are primed and waiting for a sugar rush to activate them. This metabolic readiness highlights a specialized ...

NK cells and gamma delta (γδ) T-cells – are activated to directly attack and kill tumor cells upon contact, while critically shaping the overall tumor microenvironment to be more permissive to ...

Dragonfly's TriNKET compounds are designed to activate and direct NK and cytotoxic T cell killing against cancer cells. The platform has also attracted partnerships from other pharma groups ...

For solid tumors and hematological malignancies, CAR-NK cell treatment is a novel kind of cancer immunotherapy. CAR-NK cells work by killing cancer cells in a CAR-dependent way. CAR-NK cells and ...