The Notch signaling pathway is central to a wide array of developmental processes in a number of organ systems, including hematopoiesis, somitogenesis, vasculogenesis, and neurogenesis.

The Notch family of transmembrane receptors ... which selectively inhibited NOTCH1 or NOTCH2 signalling. Receptor specificity was confirmed in vivo by the ability of the NRR1-specific and NRR2 ...

NcRNAs influence the Notch signaling pathway through several mechanisms. MiRNAs can directly target mRNAs encoding Notch receptors or ligands, thereby modulating pathway activity.