Opioids, potent pain relievers for patients with cancer, frequently cause constipation, which is a significant issue. Researchers at University of Tsukuba revealed that administering naldemedine ...

Within 4 hours of the first dose, defecation occurred in 48% of methylnaltrexone patients and in 15% of the placebo patients. Constipation is common among people who take opioids chronically.

Exclusion criteria included fecal impaction, mechanical bowel obstruction, constipation not attributed to postprocedure opioid use, calculated creatinine clearance less than 50 mL/min, and ...

Impact of Adjuvant Chemotherapy on Resected Intraductal Papillary Mucinous Neoplasm-Derived Pancreatic Cancer: Results From an International Multicenter Study Preventive use of naldemedine for ...

A complex extracted from the amniotic membrane in humans reduces post-surgical pain in mice by directly inhibiting pain-sensing neurons.

Patients with cancer starting a first-time regularly dosed strong opioid for cancer pain and age 20+ years were included. Eligible patients were randomly assigned to the naldemedine (Symproic 0.2 mg) ...

A number of doctors have voiced their concern over the sixth-most prescribed drug in the country. And in a very darkly ironic ...

This is an oral tablet that treats opioid-induced constipation, a common side effect of using opioid pain medications. Methylnaltrexone is a peripheral opioid receptor antagonist that protects ...

Mundipharma introduced a medication called Targin in 2021, which combines oxycodone with naloxone to prevent opioid-related constipation. A Mundipharma-branded video posted on a Brazilian ...

Suboxone is a combination of two drugs, buprenorphine and naloxone, that treats opioid use disorder (OUD). OUD is a real medical condition, just like diabetes or cancer, and is not anyone’s fault.

Opioid overdose deaths have dropped to the lowest they have been in three years, new estimates from the Centers for Disease Control and Prevention suggest, in the wake of a record surge of ...