肾毒性机制：与其在肾皮质，尤其是近曲小管细胞中的积累有关。这些药物可损伤刷状缘膜的完整性，导致细胞内钙稳态失衡、线粒体功能障碍、增加氧化应激，最终引起细胞损伤和凋亡。在分子水平上，氨基糖苷类还能与细胞内的磷脂和蛋白质相互作用，干扰细胞的正常代谢活动。

Previous studies have demonstrated that osteopontin, a proinflammatory cytokine, has an important role in the pathogenesis of rheumatoid arthritis (RA). To exploit osteopontin as a potential ...

The US Food and Drug Administration (FDA) has lifted the partial clinical hold on Vigil Neuroscience’s Phase I trial of ...

Objective The variety of disease phenotypes among patients with SLE challenges the identification of new biomarkers reflecting disease activity and/or organ damage. Osteopontin (OPN) is an ...

[7]骨桥蛋白（osteopontin），源自乳清蛋白粉。 [8] 中国发明专利，专利号：ZL201680013841.3，发明名称：核苷酸组合物及其在食品中的应用。返回搜狐，查看更多 责任编辑： 平台声明：该文观点仅代表作者本人，搜狐号系信息发布平台，搜狐仅提供信息存储空间服务。

Breast milk is, scientists now know, made of unique human proteins, sugars and fats, capable of delivering not only nutrition ...

Human milk osteopontin (OPN) is a bioactive protein found in breast milk that undergoes extensive post-translational processing to achieve its functionality. There is strong evidence that OPN in ...

Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy. *Corresponding Author: Elena Jachetti, Molecular Immunology Unit ...

During a 2004 study by Swedish biotech Follicum on arteriosclerosis (narrowing of the arteries), researchers discovered that osteopontin – a bone sialoprotein – stimulated hair growth. It led to the ...

3D Printing,Computed Tomography,Disc Segmentation,Fourth Segment,Intracranial Hemorrhage,Low Trauma,Minimal Trauma,Needle Puncture,Osteopontin,Path Planning,Planning ...